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diagnosis pain erythematosus arthritis msk systemic algorithm aortitis approach associations classification clues conditions connectivetissuediseases ctild dermatology extrarticular glomerulonephritis ild lungdisease
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Associated with Joint ... lesions • Discoid lupus ... #joint #pain #skin ... #rashes #differential ... #diagnosis #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Features of Systemic Lupus ... (SLE) General: ... Butterfly rash, Vasculitis ... #SLE #systemic ... symptoms #diagnosis #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Complement: Post-strep GN ... , Lupus Nephritis ... Glomerulonephritis #Vasculitis ... #differential # ... diagnosis #algorithm #rheumatology
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
Anti-retrovirals, Gemcitabine Lupus ... uncommon 5-15% of lupus ... Myopathies #myopathy #differential ... #diagnosis #comparison ... #rheumatology
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Aortitis - Differential ... ANCA associated vasculitis ... (RA), Systemic lupus ... erythematosus (SLE ... #Diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... permanent alopecia Differential ... Arthritis: • Joint ... arthropathy • 90% joints ... Erythematosus #Diagnosis #Rheumatology
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
Approach to Joint ... spondyloarthropathies, lupus ... Chronic = RA, SLE ... #rheumatology # ... approach #workup #differential
Connective tissue disease-associated interstitial lung diseases LIP: lymphoid interstitial pneumonia. NSIP: nonspecific interstitial pneumonia. OP: organizing pneumonia.
rheumatoid arthritis SLE ... : systemic lupus ... CTILD #Diagnosis #Differential ... #Comparison #Table ... #Pulmonary #Rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Scleromyxedema (CNS+GI+CVS+joints ... Autoimmunity: • -MM/WM: Vasculitis ... to cold IgG • Lupus ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... vesicular eruption - Joints ... such as systemic lupus ... , and SLE) • Urinalysis ... #rheumatology #
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