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erythematosus classification glomerulonephritis systemic vasculitis algorithm ana antibodies antinuclear arthritis autoantibodies clues disease laboratory management mimickers neurology patterns progressive rapidly
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Complement: Post-strep GN ... , Lupus Nephritis ... Glomerulonephritis #Vasculitis #differential ... #diagnosis #algorithm ... #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
Glomerulonephritis (RPGN ... IgA nephropathy, lupus ... post-infectious GN ... Classification #Differential ... #Diagnosis #Nephrology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
anemia 4% - Myositis ... involvement 3% SLE-Related ... Diagnosis and Lupus ... Lupusreference #SLE ... #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
erythematosus (SLE ... (SLE), Systemic ... Sjögren Syndrome, Myositis ... ANA #patterns #rheumatology ... #diagnosis #differential
Top 10 situations when to think about lupus 1) Inflammatory joint pain (especially in the wrists and
especially in the wrists ... the face (many differential ... diagnoses, including ... #diagnosis #sle ... erythematosus #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... permanent alopecia Differential ... Non-autoimmune rheumatologic ... • Transverse Myelitis ... #Rheumatology
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Diagnosis: • ... than 2/3 of the cross-sectional ... Evaluate for NMO, SLE ... Disorders: - SLE ... #neurology #differential
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... joint • Systemic lupus ... (to support a diagnosis ... laboratory #workup #diagnosis ... #testing #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... inflammation Others: • Lupus ... such as systemic lupus ... vasculitis, and SLE ... #diagnosis #rheumatology
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