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diagnosis differential vasculitis management ana antinuclear classification syndrome workup abnormal anca antineutrophil antinxp2 antinxp2dm antiphospholipid apls aptt arthritis autoantibodies autoimmune
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... ) • Systemic lupus ... drug-induced SLE) • Systemic ... Antineutrophil #antibodies ... #diagnosis #rheumatology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Congenital Diseases ... : • Systemic lupus ... hemoglobinuria • Antibody-mediated ... • Epstein-Barr virus ... Differential #Diagnosis #Hematology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... or Anti-NucIear Antibody ... refers to antibodies ... : Lupus (SLE), Systemic ... ANA #patterns #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... Complement: Post-strep GN ... , Lupus Nephritis ... Purpura Anti-GBM antibodies ... #rheumatology
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Differential Diagnosis Algorithm ... Inflammatory • Systemic ... Lupus Erythematosus ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... SLE-Related Auto-Antibodies ... sclerosis, Still's disease ... autoantibodies #signs ... #differential #rheumatology
Causes of Isolated Neutropenia - Differential Diagnosis Algorithm Congenital Medications • Anticonvulsants • Antibiotics • Antithyroid • Antihypertensive
Causes of Isolated ... • Epstein-Barr Virus ... Destruction • Systemic ... Lupus Erythematosus ... #Causes #Hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Early liver disease ... antiphospholipid antibodies ... FVIII antibody ... associated with systemic ... #differential #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... tract, and often causes ... purpura: strong sign ... C-ANCA) pattern: antibodies ... differential #diagnosis #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... Central nervous system ... Membranoproliferative GN ... Nephrogenic DI Hematologic ... Sjogrens #Syndrome #Rheumatology
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