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diagnosis differential vasculitis acute hematology management neurology syndrome aki ana anca antineutrophil antinuclear antinxp2 antinxp2dm antiphospholipid apls autoimmune classification dermatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... Complement: Post-strep GN ... , Lupus Nephritis ... Purpura Anti-GBM antibodies ... #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... ) • Systemic lupus ... drug-induced SLE) • Systemic ... Antineutrophil #antibodies ... #diagnosis #rheumatology
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm Acute Kidney Injury (AKI) - Acute increase
Differential Diagnosis Algorithm ... Drugs • Emboli Systemic ... Malignancy Rapidly Progressive ... Glomerulonephritis • Anti-GBM antibodies ... #Causes
Causes of Isolated Neutropenia - Differential Diagnosis Algorithm Congenital Medications • Anticonvulsants • Antibiotics • Antithyroid • Antihypertensive
Causes of Isolated ... • Epstein-Barr Virus ... Destruction • Systemic ... Lupus Erythematosus ... #Causes #Hematology
Rhombencephalitis BACTERIAL - Listeria (biphasic illness with bulbar dysfunction occurring later) - Mycobacterium tuberculosis - Pneumococcus - Brucella - Borrelia (Lyme Disease) -
Behcet Disease - Systemic ... Lupus Erythematosus ... anti-ganglioside antibody ... encephalomyelitis - Progressive ... Differential #Diagnosis #Causes
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
proteinuria, Rapidly progressing ... purpura: Strong sign ... (rapidly progressive ... tract, and often causes ... Differential #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
proteinuria, rapidly progressing ... GN • New pulmonary ... tract, and often causes ... purpura: strong sign ... C-ANCA) pattern: antibodies
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm INDICATIONS FOR TESTING: • Vascular thrombosis
Hypercoagulable Workup Algorithm ... maternal chromosomal causes ... excluded Testing: • Lupus ... Hypercoagulable #Workup #Algorithm ... #diagnosis #hematology
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
Central nervous system ... Detects both HIV antibody ... HIV-1 or HIV-2 antibodies ... IgM-sensitive HIV-1 antibody ... slow HIV disease progression
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
• Bilateral signs ... IgG index • Progression ... • Infectious causes ... glycoprotein (MOG) antibody ... Antiamphiphysin antibodies
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