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diagnosis differential symptoms vasculitis classification erythematosus hematology myositis sjogrens sle activation ana antibodies antinuclear behcet cardiology causes cryoglobulinemia cryoglobulins disease
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Positive ANA ≠ Autoimmune ... SLE), Sjogren's Syndrome ... , Sjögren Syndrome ... Thyroid, Autoimmune ... ANA #patterns #rheumatology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Wiskott-Aldrich syndrome ... Inflammatory and Autoimmune ... Diseases: • Systemic ... lupus erythematosus ... • Epstein-Barr virus
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Lupus (SLE) General ... of hip (rare), Arthritis ... Demyelinating syndromes ... erythematosus #signs ... symptoms #diagnosis #rheumatology
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
accompanies other autoimmune ... like rheumatoid arthritis ... (RA) or systemic ... lupus erythematosus ... (SLE) Signs /
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... weakness, less systemic ... anti-synthetase syndrome ... myositis, and arthritis ... Myositis #diagnosis #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
juvenile idiopathic arthritis ... lupus erythematosus ... lupus erythematosus ... #Diagnosis #Management ... #Hematology #Rheumatology
MIAMI Mnemonic for Differential Diagnosis of Lymphadenopathy Malignancies - Kaposi sarcoma, leukemias, lymphomas, metastases, skin neoplasms Infections -
toxoplasmosis Autoimmune ... Dermatomyositis, rheumatoid arthritis ... , Sjögren syndrome ... Still disease, systemic ... lupus erythematosus
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 SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... disease • Non-autoimmune ... rheumatologic diseases ... deficiencies • Autoimmune ... #Diagnosis #Rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... Mucocutaneous lymph node syndrome ... vasculitis • Behcet syndrome ... vasculitis • Cogan syndrome ... Differential #Diagnosis #Rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... infection • Autoimmune ... disorder (e.g. systemic ... lupus erythematosus ... classification #rheumatology
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