41 results
SGLT2 Inhibitors - Pharmacology Summary
Mechanisms of Action: Inhibits SGLT2 (sodium/glucose cotransporter 2) in the proximal tubule,
SGLT2 Inhibitors ... - Pharmacology ... #Pharmacology # ... Summary #DM2 #diabetes ... #endocrinology
Sulfonylureas - Pharmacology Summary
Mechanisms of Action: Binds to the ATP-sensitive potassium channel in pancreatic beta cells,
Sulfonylureas - Pharmacology ... Toxicities: Weight gain ... Sulfonylureas #Pharmacology ... #Summary #DM2 # ... diabetes #endocrinology
Profiles of Antidiabetic Medications - AACE 2018 

#Antidiabetic #Medications #Profiles #SideEffects #Table #DecisionAid #Orals #DM2 #Diabetes
DecisionAid #Orals #DM2 ... #Diabetes #Endocrinology ... #Pharmacology #
DPP-4 Inhibitors - Pharmacology Summary
Mechanisms of Action: Inhibits DPP-4 (dipeptidyl peptidase 4), which normally inactivates GLP-1
DPP-4 Inhibitors ... - Pharmacology ... #Pharmacology # ... Summary #DM2 #diabetes ... #endocrinology
Diabetes Medications Summary Table
Insulin
Lifestyle modifications
Metformin
Sulfonylureas
GLP-1 receptor agonists - ↓ major adverse CV events
TZDs
DPP-4 inhibitors
SGLT2 inhibitors -
events TZDs DPP-4 inhibitors ... SGLT2 inhibitors ... comparison #management #endocrinology ... #dm2
Effects on body weight of various classes of type-2 diabetes medications.
 - Metformin - Weight Loss
Loss + - SGLT-2 inhibitors ... Loss +++ - DPP-4 inhibitors ... Sulfonylureas - Weight Gain ... Insulin - Weight Gain ... weightgain #comparison #pharmacology
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
• Direct renin inhibitor ... Angiotensin-converting enzyme (ACE) inhibitors ... • Calcineurin Inhibitors ... #hyperkalemia #differential ... pathophysiology #pharmacology
DPP4 Inhibitors - Normal and Renal Dosing

Increase Incretins (GLP-I & GIP) -> Stimulates Insulin, Inhibits Glucagon
DPP4 Inhibitors ... Stimulates Insulin, Inhibits ... Renal #Dosing #Pharmacology ... Management #Diabetes #DM2 ... #Endocrinology
Metformin Pharmacology Summary
Mechanisms of Action:
 • Suppresses gluconeogenesis by the liver
 • Increases insulin-mediated glucose utilization
Metformin Pharmacology ... mL/minute/1.73 m2 ... #Metformin #Pharmacology ... #Summary #DM2 # ... diabetes #endocrinology
SGLT2 Inhibitors 
SGLT2 inhibitors are the newest class of anti-diabetic medications, with the first one (Canagliflozin)
SGLT2 Inhibitors ... SGLT2 inhibitors ... #Pharmacology # ... Medications #DM2 ... #Diabetes #Endocrinology