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Causes of acute kidney injury (AKI). AKI is classified into pre-renal, renal, and post-renal causes. Renal
kidney injury (AKI ... vascular supply; glomerular ... and interstitial disease ... GBM, Glomerular ... #Kidney #Injury
Acute Kidney Injury - Classification Prerenal: • Dehydration • Heart failure (a.k.a. cardiorenal syndrome) • Liver failure
Acute Kidney Injury ... - Small vessel vasculitis ... - TTP/HUS • Glomerular ... disease - Post-infectious ... #Kidney #Injury
Acute Kidney Injury (AKI) - Differential Diagnosis Framework PRE-Renal AKI: • Hypovolemia • Congestion • Medications •
Acute Kidney Injury ... • Vascular • Glomerular ... Immune-complex disease ... Bilateral ureteral disease ... #Kidney #Injury
Drug Induced Kidney Injury • Pre-Renal: NSAIDS, CNI, ACEI/ARB, IL-2 therapy, Diuretics CAR-T therapy • Osmotic
Drug Induced Kidney ... Injury • Pre-Renal ... Vitamin C • Glomerular ... Disease: Drug induced ... vasculitis, TMA
Acute Kidney Injury (AKI) - Differential Diagnosis Framework Prerenal: • Due to true volume loss or decreased
Acute Kidney Injury ... effective arterial blood ... damage to the glomeruli ... Cellular debris • Kidney ... #Kidney #Injury
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Skin, glomeruli ... : glomerular ischemia ... purpura: strong sign ... pulses, bruis, or blood ... Large Vessel: Blood
Acute Kidney Injury - Differential Diagnosis Framework PRERENAL: - Intrarenal vasoconstriction-hemodynamically mediated - Systemic vasodilation - Volume
Acute Kidney Injury ... INTRINSIC: - Glomerular ... (red blood cells ... eosinophils/white blood ... #Kidney #Injury
Causes of Acute Kidney Injury ( AKI ) - Prerenal, Renal, and Postrenal PRE-RENAL Impaired perfusion: •
Kidney Injury ( ... • Sepsis • Blood ... Small-vessel vasculitis ... • Inflammatory disease ... #Kidney #Injury
Hematuria - Differential Diagnosis Framework Gross Hematuria: Red/Dark urine • 1ml blood/liter urine can induce color change
or dipstick) Glomerular ... Immune mediated injury ... • Causes of Glomerular ... of glomerular hematuria ... Suggestive of glomerular
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
Acute Kidney Injury ... Investigations: full blood ... clinical context and signs ... Glomerulonephritis / Vasculits ... #Kidney #Injury
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