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diagnosis management hematology differential hemophagocytic lymphohistiocytosis neurology acromegaly candida candidemia cellulitis cns coagulation demyelinating dic diseases disseminated endocrinology fever fungemia
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Activation of CD8 T cells ... , Hb), Hepatic dysfunction ... Drugs, Unknown cause ... Treatment: • ... diagnosis #management #treatment
Hemophagocytic Lymphohistiocytosis (HLH) Treatment Primary HLH: - HLH-94 Protocol • Dexamethasone
) Treatment Primary ... (depending on CNS ... hematopoietic cell ... Hematopoietic cell ... #Treatment #management
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
cytopenias and organ dysfunction ... hyperinflammatory syndrome caused ... Persistent fever, organ dysfunction ... search for and treatment ... Treatment Approach
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Schistocytes, helmet cells ... + Bleeding Treatment ... Treat primary cause ... Coagulation #diagnosis #causes ... #treatment #management
IDSA Algorithm for the Management of Purulent skin and soft tissue infections (SSTIs). Mild infection: for
IDSA Algorithm for ... 12 000 or <400 cells ... oral antibiotic treatment ... evidence of organ dysfunction ... including those caused
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm Structural Defect - Asplenia/HypospIenism • Bacteremia/Septic
Causes of Fever ... Encapsulated Bacteria Cell ... jirovecii • CNS ... or Neutrophil Dysfunction ... #Causes #Hematology
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
bowel or bladder dysfunction ... that results in CNS ... Autonomic Dysfunction ... Pleocytosis > 100 cells ... Transverse Myelitis Treatment
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook Clinical Presentation: • Classic Acromegaly: frontal
Mortality due to CVD ... pancreatic islet cell ... adenoma, ↓(TFT, LH ... or refractory cases ... Endocrinology #Treatment
Langerhans Cell Histiocytosis (LCH) Granulomatous Lesions comprising langerin-positive histiocytes and an inflammatory infiltrate can arise in virtually
• Endocrine Dysfunction ... marrow: Organ dysfunction ... CNS involvement: ... TREATMENT OPTIONS ... with appropriate treatment
DEMYELINATING DISEASES OF THE CENTRAL NERVOUS SYSTEM What Are Demyelinating Diseases? • Conditions that damage myelin, the protective
nervous system (CNS ... Oligoclonal bands, cell ... area postrema (nausea ... autoimmune/infectious causes ... bladder/bowel dysfunction
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