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diagnosis differential workup causes hemolytic pancytopenia agglutinin dermatology disorders evaluation extravascular hemolysis hepatic hepatology incomplete intravascular kawasaki laboratory liverfailure naildisorders
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... • hemolytic anemia ... Positive Coombs testing ... temperatures by fixing complement ... #hematology #diagnosis
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Differential Diagnosis Algorithm ... Agglutination - Cold ... #workup #hematology ... #testing
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Warm AIHA • Cold ... perfringens - Complement-Mediated ... • Cold AIHA ... immune-complex hemolytic anemia ... #Causes #Hematology
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
secondary to Systemic Diseases ... Nail Fold Abnormality ... Iron deficiency anemia ... Systemic #Secondary #dermatology ... Differential #Diagnosis #Algorithm
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
practices that could ... smear, HIV/HCV testing ... PT, aPTT(liver disease ... changes), high MCV anemia ... bypass), LFT (liver disease
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Differential Diagnosis Algorithm ... Eating disorders ... Acquired Aplastic Anemia ... Metastatic Disease ... #Hematology
Commonly Observed Laboratory Findings in Hepatic / Liver Failure - Elevated conjugated and unconjugated bilirubin -
Elevations of —100-fold ... chronic liver disease ... deficiency - Anemia ... leads to chronic anemia ... Laboratory #Diagnosis #Testing
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Differential Diagnosis Algorithm ... Eating disorders ... Acquired Aplastic Anemia ... Metastatic Disease ... #Hematology
Preoperative Risk Evaluation Major Pre-Op Questions: 1. Does the patient have any modifiable risk factors that could be
Performance thorough ... Ischemic heart disease ... event, follow ACC algorithm ... surgery Stress Testing ... preoperative stress testing
Evaluation of suspected incomplete Kawasaki Disease 1. AHA consensus recommendations 2. Infants ≤6 months old on day ≥7
incomplete Kawasaki Disease ... Infants ≤6 months old ... should undergo lab testing ... Albumin ≤3.0 g/dL, anemia ... purposes of this algorithm
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