445 results
Acromegaly 
Caused by over-secretion of growth hormone (GH) from the pituitary gland. 
The condition is rare
over-secretion of growth ... Symptoms #Diagnosis #Endocrinology
Growth Hormone Deficiency - Pediatrics - Testing Algorithm
 - Insulin-Like Growth Factor 1 (IGF-1) with Calculated
Growth Hormone Deficiency ... - Insulin-Like Growth ... - Insulin-Like Growth ... ARUPConsult @ARUPLabs #Growth ... Algorithm #diagnosis #endocrinology
Growth Hormone Deficiency - Adult Testing Algorithm
 - Insulin-Like Growth Factor 1 (IGF-1) with Calculated Z-Score
Growth Hormone Deficiency ... - Insulin-Like Growth ... ARUPConsult @ARUPLabs #Growth ... Algorithm #diagnosis #endocrinology
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Feedback Loop: Growth ... Hormone (GH) Growth ... pathway -> Incr cell growth ... #FeedbackLoop #endocrinology
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
Growth Hormone Excess ... excess prior to growth ... GH excess after growth ... signs #symptoms #endocrinology
Tall Stature - Differential Diagnosis Algorithm

Normal Growth (BA=CA)
 • Familial Tall Stature
 • XYY Syndrome
Obese BMI
Algorithm Normal Growth ... Syndrome (Normalizing growth ... Diagnosis #Algorithm #endocrinology
Acromegaly Testing Algorithm
INDICATIONS FOR TESTING:
 • Adults – enlarged facial or acral features, abnormal musculoskeletal growth
musculoskeletal growth ... accelerated linear growth ... with 75 g load • Growth ... Algorithm #diagnosis #endocrinology
Hirsutism - Differential Diagnosis
Defined as excessive dark, coarse, male-pattern hair growth
Hirsutism causes in premenopausal women:
 •
male-pattern hair growth ... Differential #Diagnosis #endocrinology
Congenital Adrenal Hyperplasia - 21-Hydroxylase Deficiency - Signs and Symptoms
 • Brain: Androgenization effects, Glucocorticoid effects,
Male-pattern hair growth ... Accelerated childhood growth ... Symptoms #diagnosis #endocrinology
Clinical Effects of Large and Small Pituitary Tumours
Local complications - Headache, Visual field defect, Disconnection hyperprolactinaemia,
Hypopituitarism • Growth ... Symptoms #Diagnosis #Endocrinology