1082 results
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Feedback Loop: Growth ... Hormone (GH) Growth ... pathway -> Incr cell growth ... lipolysis Signs/Symptoms
Symptoms of Hypophosphatemia
 • CNS: Seizures, Delirium, Paresthesias, Central & extrapontine myelinolysis, Hallucinations, Fatigue
 • Hematologic:
Symptoms of Hypophosphatemia ... Osteomalacia, Growth ... Hypophosphatemia #Phosphate #Symptoms
Acromegaly 
Caused by over-secretion of growth hormone (GH) from the pituitary gland. 
The condition is rare
over-secretion of growth ... Acromegaly #Signs #Symptoms
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
Growth Hormone Excess ... excess prior to growth ... GH excess after growth ... diagnosis #signs #symptoms
Congenital Adrenal Hyperplasia - 21-Hydroxylase Deficiency - Signs and Symptoms
 • Brain: Androgenization effects, Glucocorticoid effects,
Deficiency - Signs and Symptoms ... Male-pattern hair growth ... Accelerated childhood growth ... Deficiency #Signs #Symptoms
CLINICAL MANIFESTATIONS 
OF ADRENAL INSUFFICIENCY. 

Primary and secondary adrenal insufficiency:
 - Tiredness, weakness, mental depression
nervous system symptoms ... - Prepubertal growth ... Headache, visual symptoms ... Insufficiency #Signs #Symptoms
Pulmonary Aspergillosis
Main Culprits: Aspergillus fumigatus, Less commonly: Aspergillus flavus, Aspergillus terreus
Diagnosis: Characteristic imaging + symptoms +
Characteristic imaging + symptoms ... Aspergillus IgG / growth
Assessment of the Child with Chronic Asthma
Are there other allergic disorders?
 - Allergic rhinitis
 - Eczema,
Finger clubbing - Growth ... and frequency of symptoms
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
(placenta/Bone growth ... Most common symptoms ... disease - Bone symptoms
Clinical Effects of Large and Small Pituitary Tumours
Local complications - Headache, Visual field defect, Disconnection hyperprolactinaemia,
Hypopituitarism • Growth ... Tumors #Signs #Symptoms