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endocrinology diagnosis differential causes pathophysiology pituitary acromegaly excess hypothyroid hypothyroidism management obesity overproduction pediatrics sellarmass shortstature signs symptoms tallstature testing
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... /Symptoms: • GH ... abn lipid • GH ... metabolic abn #GrowthHormone ... #GH #FeedbackLoop
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
time of onset of GH ... GH excess prior ... GH excess after ... fraction • HTN #GrowthHormone ... #GH #Excess #Overproduction
Sellar / Pituitary Mass - Differential Diagnosis Algorithm Adenoma - Primary Anterior Pituitary - Secreting
Differential Diagnosis Algorithm ... Prolactin • GH ... Differential #Diagnosis #Algorithm
Algorithmic Approach to Hypothyroidism - Differential Diagnosis and Management Framework Central Hypothyroidism (Secondary or tertiary) ↓TSH, ↓FT4
Algorithmic Approach ... ↓FT4 • Post-GH ... Differential #Diagnosis #algorithm
Short Stature - Differential Diagnosis Algorithm Normal Variant, Normal Puberty Onset (BA = CA) • Familial Short
Differential Diagnosis Algorithm ... Cushing's Disease • GH ... Differential #Diagnosis #Algorithm
Tall Stature - Differential Diagnosis Algorithm Normal Growth (BA=CA) • Familial Tall Stature • XYY Syndrome Obese BMI
Differential Diagnosis Algorithm ... Puberty Onset • GH ... Differential #Diagnosis #Algorithm
Weight Gain / Obesity - Differential Diagnosis Algorithm Decreased Expenditure: • Sedentary Lifestyle • Smoking Cessation
Differential Diagnosis Algorithm ... Hypogonadism • GH ... Differential #Diagnosis #Algorithm
Acromegaly Testing Algorithm INDICATIONS FOR TESTING: • Adults – enlarged facial or acral features, abnormal musculoskeletal growth
Acromegaly Testing Algorithm ... Growth Hormone (GH ... Acromegaly #Testing #Algorithm
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