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diagnosis endocrinology algorithm differential causes pathophysiology acromegaly pituitary clinical management msk signs symptoms blanching bruise diplopia ecchymosis excess feedbackloop fracture
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... /Symptoms: • GH ... abn lipid • GH ... metabolic abn #GrowthHormone ... #GH #FeedbackLoop
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
time of onset of GH ... GH excess prior ... GH excess after ... fraction • HTN #GrowthHormone ... #GH #Excess #Overproduction
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook Clinical Presentation: • Classic Acromegaly: frontal
enlargement - If GH ... • GH stimulates ... adenomas are mixed GH ... level (↑Sens) - GH ... (Lanreotide) ± GH
Acromegaly Caused by over-secretion of growth hormone (GH) from the pituitary gland. The condition is rare
growth hormone (GH
Sellar / Pituitary Mass - Differential Diagnosis Algorithm Adenoma - Primary Anterior Pituitary - Secreting
Prolactin • GH
Short Stature - Differential Diagnosis Algorithm Normal Variant, Normal Puberty Onset (BA = CA) • Familial Short
Cushing's Disease • GH
Algorithmic Approach to Hypothyroidism - Differential Diagnosis and Management Framework Central Hypothyroidism (Secondary or tertiary) ↓TSH, ↓FT4
↓FT4 • Post-GH
Tall Stature - Differential Diagnosis Algorithm Normal Growth (BA=CA) • Familial Tall Stature • XYY Syndrome Obese BMI
Puberty Onset • GH
Differential diagnoses for the neuro-ophthalmologic finding of diplopia. Neoplastic: • Intraorbital meningioma • Pituitary adenoma
Pituitary adenoma (GH
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
following order; GH
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