24 results
Proposed Treatment Algorithm for MAS / HLH

#MAS #HLH #Hemophagocytic #Lymphohistiocytosis #Management #Treatment #Algorithm #Hematology
Proposed Treatment Algorithm ... for MAS / HLH ... #MAS #HLH #Hemophagocytic ... Management #Treatment #Algorithm
Hemophagocytic Lymphohistiocytosis (HLH)
Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion
Classic lab findings in HLH: ↑↑ ferritin, Anemia,
Hemophagocytic Lymphohistiocytosis ... IL-2 receptor Diagnostic ... Criteria): Molecular diagnosis ... #Hemophagocytic ... Lymphohistiocytosis #diagnosis
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemophagocytic Lymphohistiocytosis ... Auto-amplification loop Diagnosis ... Chediak-Higashi, Griscelli, Purtilo ... #Hemophagocytic ... Lymphohistiocytosis #diagnosis
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Hemophagocytic Lymphohistiocytosis ... Presentation / Diagnosis ... Diagnosis via genetic ... Infection should be diagnosed ... #Hemophagocytic
Diagnostic Schema for Hyperferritinemia

Pearl: Diseases associated with extreme elevations: 
1. HLH 
2. Still's disease 
3. Systemic
Diagnostic Schema ... HLH 2. ... Hyperferritinemia #Algorithm ... #Differential #Diagnosis
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
acquired forms of haemophagocytic ... A subset of hemophagocytic ... lymphohistiocytosis (HLH ... hypersensitivity syndromes • HLH ... Activation #Syndrome #Diagnosis
Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
 1. Autoimmune Mediated Pancytopenia
 2. Splenic Sequestration
Peripheral Destruction
and Differential Diagnosis ... Algorithm Consumption ... and Screen for HLH ... HLH syndrome 5. ... #Algorithm #Hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
 1. Autoimmune Mediated Pancytopenia
 2. Splenic Sequestration
Peripheral Destruction
and Differential Diagnosis ... Algorithm Consumption ... and Screen for HLH ... HLH syndrome 5 ... #Algorithm #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) Diagnostic Criteria - 2004 vs 2009

At least three of the following: 
 -
Hemophagocytic Lymphohistiocytosis ... (HLH) Diagnostic ... @PulmCrit #HLH ... #Hemophagocytic ... Lymphohistiocytosis #Diagnosis
Differential Diagnosis for Generalized Lymphadenopathy

Viral
• HIV 
• EBV 
• CMV 
• HBV 
• Dengue 
• Rubella
Differential Diagnosis ... Amyloidosis • HLH ... #Differential #Diagnosis ... #Causes #Algorithm