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endocrinology hematology lymphohistiocytosis pathophysiology diagnosis management ovariancycle treatment criteria mas rheumatology activation algorithm comparison feedback follicularphase hpoa hypothalamicpituitary lutealphase macrophage
Hemophagocytic Lymphohistiocytosis (HLH) Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion Classic lab findings in HLH: ↑↑ ferritin, Anemia,
Hemophagocytic Lymphohistiocytosis ... (HLH) Clinical ... lab findings in HLH ... consistent with HLH ... #Hemophagocytic
Proposed Treatment Algorithm for MAS / HLH #MAS #HLH #Hemophagocytic #Lymphohistiocytosis #Management #Treatment #Algorithm #Hematology
Algorithm for MAS / HLH ... #MAS #HLH #Hemophagocytic
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemophagocytic Lymphohistiocytosis ... (HLH) Pathophysiology ... • Familial HLH ... Chediak-Higashi, Griscelli, Purtilo ... #Hemophagocytic
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Hemophagocytic Lymphohistiocytosis ... (HLH) Definition ... / Diagnosis: HLH ... If no response HLH ... #Hemophagocytic
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
acquired forms of haemophagocytic ... lymphohistiocytosis (sHLH ... A subset of hemophagocytic ... lymphohistiocytosis (HLH ... hypersensitivity syndromes • HLH
Menstrual Cycle Physiology: Ovarian Cycle – Brief Overview LH and FSH are required for follicular development and
Brief Overview LH ... granulosa cells - LH ... following ovulation -> LH ... -> Inhibit FSH/LH ... not implant #MenstrualCycle
Hemophagocytic Lymphohistiocytosis (HLH) Treatment Primary HLH: - HLH-94 Protocol • Dexamethasone
Hemophagocytic Lymphohistiocytosis ... (HLH) Treatment ... Primary HLH: - ... HLH-94 Protocol ... #Hemophagocytic
Menstrual Cycle Physiology: Ovarian Cycle – Ovulation Explained Around Day 14, estrogen exerts sudden +++ positive feedback
understood) -> surge in LH ... production and release LH ... 36 hours after LH ... for clarity) #MenstrualCycle
Menstrual Cycle Physiology: Ovarian Cycle – Luteal Phase Explained • The LH surge can be thought
Explained • The LH ... Day 14 surge in LH ... GnRH, FSH, and LH ... • Decreased LH ... Ovarian Cycle #MenstrualCycle
Menstrual Cycle Physiology: The Hypothalamic-Pituitary-Ovarian Axis Estrogen, when released: • Negatively feeds back on the hypothalamus and
pituitary to Increased LH ... #MenstrualCycle
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