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Cryoglobulinemia Classification Types Type 1: Monoclonal IgM (rarely IgG/lgA) • Raynaud phenomenon, Digital ulcers/gangrene, Livedo reticularis, Hyperviscosity
1: Monoclonal IgM ... (rarely IgG/lgA ... 2: Monoclonal IgM ... and polyclonal IgG ... and polyclonal IgG
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings - Infectious Agents - 50% have
IgA Vasculitis – ... Infectious Agents - 50% have ... (GD-IgA1). ... -> Decr IgA serum ... -> adhesion of IgA
Subtypes of Serum Proteins Pre-albumin (Transthyretin) Albumin Globulins • Alpha-1: Alpha-1 antitrypsin, Serum amyloid A, Ceruloplasmin, Corticosteroid-binding globulin (Transcortin),
Transferrin • Gamma: IgM ... , IgG, IgA, RF,
Management of adult IgA Vasculitis (Henoch-Schönlein purpura) - Treatment algorithm for the management of IgAV patients
Management of adult IgA ... management of IgAV ... Management of IgA ... TerrierBen #IgA ... #Vasculitis #IGAV
Diagnosis of IgA Vasculitis (Henoch-Schönlein Purpura) - French Vasculitis Study Group 1) Suggestive clinical manifestations
Diagnosis of IgA ... Elevated serum IgA ... vasculitis with IgA1 ... - Dominant IgA ... with vascular IgA
Commonly Used Diagnostic Tests for Celiac Disease Tissue transglutaminase (tTG) IgA antibodies - Most reliable noninvasive test
transglutaminase (tTG) IgA ... negative with IgA ... patients with IgA ... and specificity IgA ... disease less than IgA
Celiac Disease Testing Algorithm INDICATIONS FOR TESTING: Nonspecific symptoms (iron-deficiency anemia, failure to thrive, fever, skin
Immunoglobulin A • tTG IgA ... • tTG IgG and ... DGP IgGa • EMA ... IgG by IFA • DGP ... IgA • HLA testing
Warm vs Cold Autoimmune Hemolytic Anemia Warm Autoimmune Hemolytic Anemia: • Mechanism: IgG and Complement-mediated • Etiology:
• Mechanism: IgG ... Coombs positive for IgG ... • Mechanism: IgM ... hematology #diagnosis #comparison
You’ll notice there is an IgM and an IgG core antibody. The presence of IgM anti-HBc
notice there is an IgM ... and an IgG core ... The presence of IgM ... IgM anti-HBc is ... The presence of IgG
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm INDICATIONS FOR TESTING: • Vascular thrombosis
and IgM • Beta ... Antibodies, IgG ... Antibody, IgGa ... Cardiolipin Antibody, IgA ... Glycoprotein 1 Antibody, IgA
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