13 results
Kaposi Sarcoma Herpes Virus (KSHV)

By Dr. Sara Dong @swinndong via #IDFellowCase
#ID  #Infectious Diseases  #Infections
#Differential
Herpes Virus (KSHV ... Diseases #Infections ... Ddx #Diagnosis #KSHV ... #HHV #lymphoproliferative ... #KICS
KSHV Inflammatory Cytokine Syndrome (KICS)

By Dr. Sara Dong @swinndong  via #IDFellowCase
#ID  #Infectious Diseases
KSHV Inflammatory ... Cytokine Syndrome (KICS ... Diseases #Infections ... Ddx #Diagnosis #KSHV ... #HHV #KICS #Kaposi
HHV8/KSHV-reIated diseases: From Cellular Proliferation to Hyperinflammation
Kaposi sarcoma (KS):
 • Target organs: Ubiquitous (cutaneous and mucosal
HHV8/KSHV-reIated ... • Association HIV ... Light chain: - HHV8 ... de Fremont #HHV8 ... comparison #diagnosis #kshv
Clinical Manifestations of Human Herpes Viruses (HHV)

Herpes simplex virus 1	HSV-1	Frequently subclinical (80-90%) Oral lesions (10-20%) congenital
Herpes Viruses (HHV ... 20%) congenital infection ... herpes virus 6 HHV ... herpes virus 7 HHV ... Herpes #Viruses #HHV
KSHV Inflammatory Cytokine Syndrome (KICS)
Working Case Definition for KICS: Requires at least 2 clinical manifestations (from
Cytokine Syndrome (KICS ... Definition for KICS ... if present Infectious ... ID_fellows #KICS ... diagnosis #management #hhv8
Infection-Related Cancers
Viruses:
 • HPV - Cervical, anogenital, head and neck, skin cancer
 • HTLV-1 - Adult
Infection-Related ... Cancers Viruses: • HPV ... T-cell Leukemia • HIV ... carcinoma • HHV ... @drkeithsiau #Infection
Transplant Infections Timeline
Pre-transplant:
 • Common bacteria (endogenous): Staphylococci (skin), Gram-negative bacilli (gut)
 • Viruses: HSV (reactivation)
Engraftment:
Transplant Infections ... gut) • Viruses: HSV ... airways) • Viruses: HSV ... reactivation), HHV ... #Transplant #Infections
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Triggering factor (infection ... Acquired HLH: • Infections ... Virus (EBV, CMV, HHV8 ... Still disease, Infection ... Etiological+++: Anti-infectious
IDSA Recommendations for Preventing and Treating HHV-8 Diseases—Kaposi Sarcoma (KS), Primary Effusion Lymphoma (PEL), Multicentric Castleman’s
Preventing and Treating HHV ... and uncontrolled HIV ... activity against HHV ... adjunctive therapy #HHV8 ... opportunistic #infections
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS

What Is IRIS?
	• A state of hyperinflammatory response that
of treatment of HIV ... to an existing infection ... opportunistic infection ... an unrecognized infection ... Kaposi sarcoma, HHV8