5789 results
Hypoplastic Left Heart Syndrome (HLHS)
 • Introduction
 • Embryology
 • Anatomy
 • Physiology of HLHS
 •
Heart Syndrome (HLHS ... Physiology of HLHS ... Physical Exam/Diagnostic ... LeftHeart #Syndrome #HLHS
Hemophagocytic Lymphohistiocytosis (HLH)
Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion
Classic lab findings in HLH: ↑↑ ferritin, Anemia,
Lymphohistiocytosis (HLH ... lab findings in HLH ... IL-2 receptor Diagnostic ... Criteria): Molecular diagnosis ... Lymphohistiocytosis #diagnosis
Diagnostic Schema for Hyperferritinemia

Pearl: Diseases associated with extreme elevations: 
1. HLH 
2. Still's disease 
3. Systemic
Diagnostic Schema ... HLH 2. ... #Differential #Diagnosis
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Lymphohistiocytosis (HLH ... Presentation / Diagnosis ... Diagnosis via genetic ... Infection should be diagnosed ... Lymphohistiocytosis #diagnosis
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH ... Auto-amplification loop Diagnosis ... hemophagocytosis = additional diagnostic ... • Familial HLH ... Lymphohistiocytosis #diagnosis
Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
 1. Autoimmune Mediated Pancytopenia
 2. Splenic Sequestration
Peripheral Destruction
and Differential Diagnosis ... and Screen for HLH ... HLH syndrome 5. ... #Differential #Diagnosis
Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
 1. Autoimmune Mediated Pancytopenia
 2. Splenic Sequestration
Peripheral Destruction
and Differential Diagnosis ... and Screen for HLH ... HLH syndrome 5 ... #Differential #Diagnosis
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
- Differential Diagnosis ... erythematosus • HLH ... #Differential #Diagnosis
Differential Diagnosis for Generalized Lymphadenopathy

Viral
• HIV 
• EBV 
• CMV 
• HBV 
• Dengue 
• Rubella
Differential Diagnosis ... Amyloidosis • HLH ... #Differential #Diagnosis
Causes of Hyperferritinemia - Differential Diagnosis
Ferritin > 1000
Ferritin is the storage form of iron. Increased hepcidin
- Differential Diagnosis ... HLH or Adult Onset ... In adults, HLH is ... #Differential #Diagnosis