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diagnosis algorithm anemia oncology pathophysiology pulmonary polycythemia product reactions workup aflp aplastic arterial aspergillus betadglucan biomarkers bloodproduct boop bronchiectasis calculation
Dyspnea - Differential Diagnosis Framework Cardiovascular Causes of Dyspnea: • Myocardium: - Heart failure - CAD/ACS - Valvulopathy • Electrical: -
Dyspnea - Differential ... • Parenchyma: ILD ... Water - Pus - Blood ... Transverse myelitis • Hematology ... #dyspnea #sob #differential
Blood Product Components, Contents, Volume and Shelf Life Whole blood (autologous or directed donations) - RBC and
Hct 35%. 450mL blood ... red cells have a Hct ... Hct 60% Platelet ... Contents #Volume #Hematology ... #Management #Table
Erythrocytosis - Polycythemia Differential Diagnosis Algorithm Elevated Hemoglobin: • Males: Hb > 16.5 g/dL/HCT ≥ 49% •
- Polycythemia Differential ... Hb > 16.5 g/dL/HCT ... : Hb > 16 g/dL/HCT ... Polycythemia - Acquired Causes ... Diagnosis #Algorithm #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
= (Retic %) x (Hct ... the peripheral blood ... > 3: • Acute blood ... Production #Index #hematology ... #anemia #differential
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Phagocytosis of blood ... cytokines (TNFa,lL1, IL6 ... Drugs, Unknown cause ... PTLD), allogeneic HSCT ... Lymphohistiocytosis #diagnosis #management
Cryptogenic Organizing Pneumonia (COP) Cryptogenic Organizing Pneumonia Overview: • Idiopathic form of organizing pneumonia • formerly BOOP
- Imaging: • CXR ... , cavities • HRCT ... • Pneumonia: blood ... BOOP #pulmonary #ILD ... #diagnosis #management
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Polycythemia - Differential ... Hb>16.5 g/dL, Hct ... Hb>16.0 g/dL, Hct ... Better call hematology ... Algorithm #workup #hematology
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
infection (IFI) in hematologic ... albumin, or other blood ... and allogeneic HSCT ... BAL GM does not differentiate ... 100d following HSCT
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
= nonspecific (nausea ... AP, ↑INR, ↑BUN/Cr ... ↓Antithrombin Ill ... infiltration) Differential ... Liver #Pregnancy #hepatology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Arterial Thrombosis - Differential ... contraceptives - HRT ... Ischemic Liver, IBD ... pathophysiology #hematology ... #differential #
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