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diagnosis algorithm oncology blood pathophysiology polycythemia pulmonary reactions thrombosis venous workup aflp anemia aplastic aspergillus betadglucan biomarkers bloodproduct boop bronchiectasis
Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework STRUCTURAL: - PFO: paradoxical emboli - Popliteal
Causes of Arterial ... Venous Thrombosis - Differential ... artery aneurysm: Causes ... Lipoprotein a ↑ - IBD ... Diagnosis #clots #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Thrombosis - Differential ... Ischemic Liver, IBD ... coagulation and other causes ... pathophysiology #hematology ... #differential #
Blood Product Components, Contents, Volume and Shelf Life Whole blood (autologous or directed donations) - RBC and
Blood Product Components ... Hct 35%. 450mL blood ... red cells have a Hct ... Hct 60% Platelet ... Contents #Volume #Hematology
Erythrocytosis - Polycythemia Differential Diagnosis Algorithm Elevated Hemoglobin: • Males: Hb > 16.5 g/dL/HCT ≥ 49% •
- Polycythemia Differential ... Hb > 16.5 g/dL/HCT ... : Hb > 16 g/dL/HCT ... Polycythemia - Acquired Causes ... Diagnosis #Algorithm #hematology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
acid metabolism products ... AP, ↑INR, ↑BUN/Cr ... ↓Antithrombin Ill ... infiltration) Differential ... Liver #Pregnancy #hepatology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Polycythemia - Differential ... Hb>16.5 g/dL, Hct ... Hb>16.0 g/dL, Hct ... Better call hematology ... Algorithm #workup #hematology
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
infection (IFI) in hematologic ... or other blood products ... and allogeneic HSCT ... BAL GM does not differentiate ... 100d following HSCT
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
May have drop in Hct ... Causes purpura & ... TRALI): Leading cause ... Transfusions #diagnosis #management ... #hematology #reactions
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
Fibrin degradation products ... decrease in most cases ... WBC count and differential ... hematuria (without casts ... Diagnosis #Workup #Hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
May have drop in Hct ... Causes purpura & ... TRALI): Leading cause ... Transfusion #diagnosis #management ... #hematology #reactions
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