22 results
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... Viral infections (HAV ... , HBV, HCV, HEV, ... dechallenge • Acute ... #Algorithm #hepatology
Chronic Hepatitis B - Diagnosis and Management Algorithm

• Who to treat: Essentially treat the pts with
pts with chronic HBV ... phases of chronic HBV ... Quant HBV DNA. ... HAV immunity; Liver ... reservoir of HBV
Hepatitis B - Treatment Indications
Treatment not indicated:
 • Immune tolerant state - HBe-Ag detectable, high HBV
severe liver injury ... > 3 mg/dL) or acute ... liver failure ... #Indications #management ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... • Infectious: HAV ... , HBV, HCV, HEV, ... EBV, HSV, CMV, ... #hepatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Causes of Acute ... Liver Injury - Differential ... , CMV, HSV • Toxic ... #Injury #Differential ... #algorithm #hepatology
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
arthritis, Skin rash ... borrelia, Rubeola, HBV ... , HIV, HTLVI, Hantavirus ... Disease #diagnosis #management ... #treatment #rheumatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Injuryliver ... Hepatitis A/B/C/D/E, EBV ... , CMV, HSV, VZV ... #Diagnosis #hepatology ... #algorithm #Transaminitis
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
deficiency • Liver ... - APLS • Acute ... • HCV, HBV Not ... Differential #Diagnosis #hematology ... #rheumatology #
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
hepatitis serologies, HCV ... hepatitis serologies, HCV ... injury < 26 weeks ... disease: > 2 • NASH ... #differential #Hepatology
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver ... > 20x normal - Acute ... normal - Infection (EBV ... normal - Hemolysis, NASH ... #Injury #hepatology