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hepatology differential algorithm rheumatology hepatitis transaminitis causes acute blood comparison druginduced gastroenterology lupus product reactions sle stills treatment aclf adult
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... Stepwise Diagnosis ... disease, Hepatic ... #Liver #Injury ... #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Injury (DILI) ... presentation • Chronic ... - ongoing ↑ LFTs ... disease 6-9 mo
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... Cirrhosis • Chronic ... Viral Hepatitis ... (>1000): • DILI ... injury) • Ischemic
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential Diagnosis ... • NASH, Chronic ... : > 3 • Chronic ... #injury #hepatitis
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
- Differential Diagnosis ... Trauma: Shock liver ... Metabolic: Wilson Disease ... • Iatrogenic: DILI ... #causes #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... disease, liver ... Injury (DILI) ... #Cirrhosis #Hepatology ... #diagnosis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... disease: > 2 ... • NASH, Chronic ... : > 3 • Chronic ... #chemistry #diagnosis
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... 5-10x normal - Chronic ... #Injury #hepatology ... #LFTs #transaminitis ... #differential #diagnosis
Chronic Hepatitis B - Diagnosis and Management Algorithm • Who to treat: Essentially treat the pts with
Chronic Hepatitis ... HAV immunity; Liver ... Chronic Hepatitis ... #HepatitisB #HBV ... #Hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
: Liver Injury ... D/E, EBV, CMV, HSV ... #Diagnosis #hepatology ... Transaminitis #LFTs ... #hepatitis
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