27 results
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis ... duration), Several medications ... non-essential drug/HDS treatments ... disease, Hepatic ... #Injury #Diagnosis
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... - Differential Diagnosis ... • NASH, Chronic ... #differential #diagnosis ... #algorithm #hepatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Injury - Differential ... Diagnosis Hepatocellular ... , D, EBV, CMV, HSV ... Toxic: Alcohol, Medication ... #Diagnosis #Causes
Hepatitis B - Treatment Indications
Treatment not indicated:
 • Immune tolerant state - HBe-Ag detectable, high HBV
Indications Treatment ... injury (INR > 2 ... mg/dL) or acute liver ... #Treatment #Indications ... #management #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
: Liver Injury ... D/E, EBV, CMV, HSV ... , VZV • Medications ... HELLP, Celiac disease ... #Diagnosis #hepatology
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
arthritis, Skin rash ... Differential Diaqnoses ... borrelia, Rubeola, HBV ... #diagnosis #management ... #treatment #rheumatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
months without treatment ... disease, liver ... Injury (DILI) ... Failure #Cirrhosis #Hepatology ... #diagnosis
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
of cholestatic disease ... disease: > 2 ... • NASH, Chronic ... #chemistry #diagnosis ... #differential #Hepatology
Shock - Differential Diagnosis Framework
 - MAP <65. SBP <90, drop in SBP > 40
 -
Insufficiency, Liver ... Failure, Toxins/Medications ... , Spinal Cord Injury ... , Severe Valve Disease ... #management
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
from subclinical disease ... to acute liver ... injury, though ... regarding need for treatment ... #Management #Hepatology