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antibodies lupus patterns sle anca antineutrophil arthritis associations druginduced laboratory management monoclonal oncology pancytopenia paraproteinemias rheumatic rheumatoid testing
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Associated Rheumatic Diseases ... connective tissue disease ... SLE), Sjogren's Syndrome ... #patterns #rheumatology ... #diagnosis #differential
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
connective tissue disease ... 90% • Anti-GBM disease ... #Antinuclear #Antibody ... #rheumatology # ... diseases
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and ... their Disease Associations ... (TTG) - Celiac disease ... #diagnosis #table ... #rheumatology #
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antibody refers ... Disease! ... Rheumatic Diseases ... #patterns #rheumatology ... #diagnosis #differential
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Diseases: • GATA2 ... Autoimmune Diseases ... : • Systemic lupus ... erythematosus ... #Diagnosis #Hematology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
and Systemic lupus ... Association with disease ... with auto-immune diseases ... #diagnosis #rheumatology ... #table #ANA
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Decade Skin Disease ... Diagnosis: • ANCA-associated ... tissue disease ... diseases (i.e. ... #Diagnosis #Rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... Studies in Rheumatic Diseases ... connective-tissue disease ... #Rheumatic #Disease ... #Rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... Sneddon-Wilkinson disease ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
of autoantibodies ... Lupus Erythematosus ... Evolution: Chronic disease ... #table #rheumatology ... #diagnosis #management
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