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lupus antibodies differential management sle table anca antineutrophil antinxp2dm arthritis autoimmune cll comparison criteria dermatomyositis dermatosis druginduced febrile laboratory leukemia
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
connective tissue disease ... 90% • Anti-GBM disease ... #Antinuclear #Antibody ... #rheumatology # ... diseases
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antibody refers ... Disease! ... context of other symptoms ... #patterns #rheumatology ... #diagnosis #differential
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
and Systemic lupus ... with disease activity ... with auto-immune diseases ... #autoantibodies ... #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Decade Skin Disease ... tissue disease ... diseases (i.e. ... ) • Kikuchi disease ... #Diagnosis #Rheumatology
Diagnostic Criteria for Sweet Syndrome (Acute Febrile Neutrophilic Dermatosis) Major criteria 1. Abrupt onset of tender
onset of tender erythematous ... Association with ... an underlying hematologic ... inflammatory disease ... #Hematology #Dermatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... Studies in Rheumatic Diseases ... connective-tissue disease ... #Rheumatic #Disease ... #Rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
of autoantibodies ... Lupus Erythematosus ... • Evolution: Chronic ... disease Dr. ... comparison #table #rheumatology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
without these autoantibodies ... levels • NXP-2 antibody ... had more severe disease ... #rheumatology # ... dermatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... cells can indicate disease ... ’s lymphoma or acute ... #workup #oncology ... #hematology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Interstitial lung disease ... Interstitial lung disease ... Interstitial lung disease ... skeletal muscle disease ... Myositis #Myopathy #rheumatology
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