Haglund syndrome rheumatology workup ucl autoantibodies diseases systemic antinuclear ana patterns antibodies disease autoimmune management

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Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like

Antinuclear Antibodies ... Positive ANA ≠ Autoimmune ... : The ANA patterns ... #Antibodies #ANA ... #patterns #rheumatology

ANA Patterns and Associated Rheumatic Diseases:
• Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease

ANA Patterns and ... Associated Rheumatic Diseases ... connective tissue disease ... #Antibodies #ANA ... #patterns #rheumatology

Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA

Autoantibodies and ... their Disease Associations ... (TTG) - Celiac disease ... #Associations #diseases ... #antibodies

ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
• Systemic lupus erythematosus
1. Anti-dsDNA

ANA (Antinuclear ... connective tissue disease ... 90% • Anti-GBM disease ... #rheumatology # ... diseases

Antinuclear antibodies and Systemic lupus
Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can

Antinuclear antibodies ... and Systemic lupus ... Association with disease ... with auto-immune diseases ... #autoantibodies

IgG4-Related Disease
Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
•

Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease

multisystemic disease ... associated with other diseases ... demyelinating disease ... peripheral Thyroid Disease ... Tracheobronchial disease

SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and

Decade Skin Disease ... tissue disease ... rheumatologic diseases ... (e.g. thyroid disease ... ) • Kikuchi disease

Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis

OnePager Summary Autoimmune ... life-threatening diseases ... Inflammatory eye disease ... EGPA) • Auto-antibodies ... • IF staining patterns

Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain

Interstitial lung disease ... Interstitial lung disease ... Interstitial lung disease ... skeletal muscle disease ... myocarditis Other Diseases

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