Haglund syndrome rheumatology workup ucl autoantibodies diseases systemic antinuclear ana patterns antibodies disease autoimmune management related antineutrophil diagnosis

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Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like

Antinuclear Antibodies ... Positive ANA ≠ Autoimmune ... #Antibodies #ANA ... #patterns #rheumatology ... #diagnosis #differential

ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
• Systemic lupus erythematosus
1. Anti-dsDNA

ANA (Antinuclear ... connective tissue disease ... 90% • Anti-GBM disease ... #antibodies #diagnosis ... diseases

ANA Patterns and Associated Rheumatic Diseases:
• Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease

ANA Patterns and ... Associated Rheumatic Diseases ... connective tissue disease ... #Antibodies #ANA ... #patterns #rheumatology

Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA

Autoantibodies and ... their Disease Associations ... ANA - Non-specific ... (TTG) - Celiac disease ... antibodies

IgG4-Related Disease
Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
•

Antinuclear antibodies and Systemic lupus
Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can

Antinuclear antibodies ... and Systemic lupus ... Association with disease ... with auto-immune diseases ... #autoantibodies

Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease

multisystemic disease ... associated with other diseases ... demyelinating disease ... Tracheobronchial disease ... Diagnosis #Management

SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and

Decade Skin Disease ... tissue disease ... rheumatologic diseases ... (e.g. thyroid disease ... ) • Kikuchi disease

Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis

OnePager Summary Autoimmune ... life-threatening diseases ... Inflammatory eye disease ... EGPA) • Auto-antibodies ... • IF staining patterns

Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain

Interstitial lung disease ... Interstitial lung disease ... Interstitial lung disease ... skeletal muscle disease ... myocarditis Other Diseases

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