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diagnosis differential lupus management table anca antibody antineutrophil aortitis arthritis classification druginduced laboratory phenotypes rheumatoid testing treatment vasculitides vasculitis
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... Diseases: • Homogeneous ... tissue disease ... #Antibodies #ANA ... #patterns #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Rheumatic Diseases ... • Rheumatic Diseases ... #Antibodies #ANA ... #patterns #rheumatology
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
polychondritis, Behcet's Disease ... Diseases: IgG4- ... Related Disease ... (IgG4-RD), Rheumatoid ... (SLE), Sarcoidosis
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... erythematosus ... connective tissue disease ... 90% • Anti-GBM disease ... diseases
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
IgG4-Related Disease ... female, asian • Systemic ... (antinuclear antibodies ... , rheumatoid factor ... #Related #Disease
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... and Systemic lupus ... Association with disease ... with auto-immune diseases ... #autoantibodies
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Decade Skin Disease ... tissue disease ... diseases (i.e. ... ) • Kikuchi disease
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... Diseases • Septic ... (SLE) - Antinuclear ... connective-tissue disease ... #Disease #Rheumatoid
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
95% (IgG anti-chromatin ... of autoantibodies ... Lupus Erythematosus ... Evolution: Chronic disease ... #rheumatology #
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
(Granulomatous disease ... rheumatic diseases ... atherosclerotic disease ... most important diseases ... ) pattern: antibodies
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