Haglund syndrome rheumatology workup ucl autoantibodies diseases systemic antinuclear ana patterns antibodies disease sle oncology igg4 hematology

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ANA Patterns and Associated Rheumatic Diseases:
• Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease

ANA Patterns and ... Associated Rheumatic Diseases ... connective tissue disease ... #Antibodies #ANA ... #patterns #rheumatology

Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like

Antinuclear Antibodies ... Disease! ... : Lupus (SLE), Systemic ... #Antibodies #ANA ... #patterns #rheumatology

Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA

Autoantibodies and ... their Disease Associations ... ANA - Non-specific ... (TTG) - Celiac disease ... diagnosis #table #rheumatology

ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
• Systemic lupus erythematosus
1. Anti-dsDNA

ANA (Antinuclear ... connective tissue disease ... 90% • Anti-GBM disease ... #rheumatology # ... diseases

Antinuclear antibodies and Systemic lupus
Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can

Antinuclear antibodies ... and Systemic lupus ... Association with disease ... with auto-immune diseases ... erythematosus #diagnosis #rheumatology

IgG4-Related Disease
Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
•

SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and

SLE (Systemic Lupus ... Decade Skin Disease ... tissue disease ... diseases (i.e. ... Erythematosus #Diagnosis #Rheumatology

Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone

• Heavy Chain disease ... anemia due to cold IgG ... Sneddon-Wilkinson disease ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology

Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease

multisystemic disease ... associated with other diseases ... demyelinating disease ... Tracheobronchial disease ... #Rheumatology #

Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
• Epidemiology: -10% of all lupus cases, drug-dependent,

95% (IgG anti-chromatin ... of autoantibodies ... months to years) Systemic ... Evolution: Chronic disease ... comparison #table #rheumatology

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