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differential associations classification antineutrophil cryoglobulins laboratory patterns rheumatic sle testing types
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... ) • Systemic lupus ... Vasculitis: • ... Renal-limited vasculitis ... #antibodies #diagnosis
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Lupus (SLE): ANA ... others (RNP, aPL antibodies ... • Scleroderma (Systemic ... Ill • ANCA Vasculitis ... #table
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and ... ANA - Non-specific ... c-ANCA - Vasculitis ... - Vasculitis, e.g ... #diagnosis #table
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Rheumatic Diseases ... lupus erythematosus ... • Rheumatic Diseases ... #Antibodies #ANA
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitis: + MPO-ANCA ... : Systemic rheumatic ... diseases, such ... as systemic lupus ... LFT • ESR • ANA
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Autoimmune diseases ... DDX: • ANCA (Antineutrophil ... • Vasculitis ... lupus erythematosus ... #vasculitis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
vasculitis, rheumatoid ... • Mesenteric vasculitis ... inflammation Cutaneous Vasculitis ... • (-) ANA + (+ ... #Diagnosis #Rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
: • Systemic rheumatic ... diseases, such ... atherosclerotic disease ... most important diseases ... (GRANULOMATOUS DISEASE
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... lupus erythematosus ... antibody (ANA) ... #Disease #Rheumatoid ... #workup #diagnosis
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