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diagnosis differential ana antinuclear lupus sle table classification patterns vasculitis antineutrophil associations cryoglobulinemia cryoglobulins druginduced laboratory management mimickers myopathy myositis
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
their Disease Associations ... connective tissue disease ... (TTG) - Celiac disease ... #Associations #diseases ... #antibodies
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antibody) and ANCA ... erythematosus ... connective tissue disease ... 90% • Anti-GBM disease ... diseases
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antibody refers ... Positive ANA ≠ Autoimmune ... Disease! ... • Rheumatic Diseases ... #rheumatology #diagnosis
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Associated Rheumatic Diseases ... connective tissue disease ... Juvenile Idiopathic Arthritis ... SLE), Sjogren's Syndrome ... #rheumatology #diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Decade Skin Disease ... rheumatologic diseases ... (e.g. thyroid disease ... ) • Kikuchi disease ... • Castleman's disease
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Manifestations: - Arthritis ... SLE-Related Auto-Antibodies ... auto-immune, Infectious diseases ... sclerosis, Still's disease
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
pain • Kawasaki Disease ... (Granulomatous disease ... rheumatic diseases ... atherosclerotic disease ... most important diseases
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... Studies in Rheumatic Diseases ... exclude inflammatory disease ... connective-tissue disease ... #Rheumatic #Disease
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
diseases: - 10% ... DDX: • ANCA (Antineutrophil ... cytoplasmic antibody ... lupus erythematosus ... classification #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Constitutional symptoms, Arthritis ... months to years) Systemic ... Lupus Erythematosus ... Evolution: Chronic disease ... #table #rheumatology
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