Haglund syndrome rheumatology workup ucl autoantibodies diseases systemic disease antibodies table autoimmune igg4 cvid monoclonal erythematosus diagnosis hematology

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Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA

their Disease Associations ... (TTG) - Celiac disease ... #diagnosis #table ... #rheumatology # ... antibodies

Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like

Disease! ... connective tissue disease ... • Rheumatic Diseases ... ANA #patterns #rheumatology ... #diagnosis #differential

SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and

Decade Skin Disease ... rheumatologic diseases ... (e.g. thyroid disease ... ) • Kikuchi disease ... #Diagnosis #Rheumatology

ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
• Systemic lupus erythematosus
1. Anti-dsDNA

erythematosus ... connective tissue disease ... 90% • Anti-GBM disease ... #diagnosis #rheumatology ... #diseases

IgG4-Related Disease
Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
•

Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
1. Cold Agglutinins (CAD)
2. Donath-Landsteiner

Cold Agglutinin Disease ... Cold Agglutinin Disease ... disease (younger ... cold #agglutinin #disease ... hemolytic #anemia #hematology

Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell

• Chronic lung disease ... Granulomatous disease ... • Liver diseases ... interstitial lung disease ... hypogammaglobulinemia #immunology #hematology

Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone

• Heavy Chain disease ... anemia due to cold IgG ... Sneddon-Wilkinson disease ... Paraproteinemias #Hematology ... #Diagnosis #Oncology

Antinuclear antibodies and Systemic lupus
Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can

Antinuclear antibodies ... Association with disease ... with auto-immune diseases ... #diagnosis #rheumatology ... #table #ANA

Cryoglobulinemia Summary

Cryoglobulins:
• Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below

activate the immune system ... diseases: - 10% ... Labs/Diagnosis: ... lupus erythematosus ... classification #rheumatology

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