Haglund syndrome rheumatology workup ucl autoantibodies diseases systemic lupus disease patterns treatment anca classification antinuclear vasculitides

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ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
• Systemic lupus erythematosus
1. Anti-dsDNA

ANA (Antinuclear ... lupus erythematosus ... connective tissue disease ... 90% • Anti-GBM disease ... #diseases

ANA Patterns and Associated Rheumatic Diseases:
• Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease

ANA Patterns and ... Associated Rheumatic Diseases ... connective tissue disease ... SLE), Sjogren's Syndrome ... #patterns #rheumatology

Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like

Disease! ... : The ANA patterns ... Rheumatic Diseases ... : Lupus (SLE), Systemic ... #patterns #rheumatology

Classification of Vasculitis
Vasculitis of large vessels
- Arteritis temporalis (giant-cell arteritis)
- Takayasu

Classification of ... - Kawasaki disease ... small vessels - ANCA-associated ... lupus erythematosus ... #Diagnosis #Rheumatology

Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
•

pain • Kawasaki Disease ... (Granulomatous disease ... rheumatic diseases ... atherosclerotic disease ... most important diseases

Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
• Associated

Systemic Lupus Erythematosus ... - Summary Antinuclear ... with more severe disease ... Used to monitor disease ... Treatment: •

Antinuclear antibodies and Systemic lupus
Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can

and Systemic lupus ... Association with disease ... with auto-immune diseases ... #autoantibodies ... #Systemic #lupus

SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and

SLE (Systemic Lupus ... Decade Skin Disease ... Classification: ... diseases (i.e. ... ) • Kikuchi disease

Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
• Epidemiology: -10% of all lupus cases, drug-dependent,

• Immunologic Workup ... months) and of autoantibodies ... months to years) Systemic ... Evolution: Chronic disease ... comparison #table #rheumatology

IgG4-Related Disease
Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
•

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