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differential antinuclear management sle antibody antineutrophil arthritis associations classification comparison druginduced inflammatory myopathy myositis patterns rheumatic rheumatoid tafro testing thrombocytopenia
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear Visual or auditory symptoms in conjunction
BEE Syndromes - ... less common diseases ... • Systemic lupus ... spectrum disorder • ANCA-associated ... #Syndromes #neurology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Positive ANA ≠ Autoimmune ... • +ANA can be seen ... SLE), Sjogren's Syndrome ... Arthritis, Sjögren Syndrome ... #rheumatology #diagnosis
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and ... ANA - Non-specific ... La) - Sjogren's syndrome ... Goodpasture's syndrome ... #diagnosis #table
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
) • Systemic lupus ... cases • Sjögren syndrome ... connective tissue disease ... #diagnosis #rheumatology ... #diseases
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
rheumatologic diseases ... lymphoma • Evans' syndrome ... Shrinking lung syndrome ... • (-) ANA + (+ ... #Diagnosis #Rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
and Systemic lupus ... Association with disease ... SLE-SSc-AlM overlap syndromes ... #diagnosis #rheumatology ... #table #ANA
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
: - ANA > ... of autoantibodies ... Lupus Erythematosus ... : - ANA > ... Evolution: Chronic disease
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Mucocutaneous lymph node syndrome ... VASCULITIS: • Behçet Syndrome ... • Cogan Syndrome ... diseases, such ... as systemic lupus
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... Studies in Rheumatic Diseases ... lupus erythematosus ... #Rheumatic #Disease ... #workup #diagnosis
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
• Anti-NXP2 (ANA ... (ANA present 80% ... Antisynthetase syndrome ... ANTI-SYNTHETASE SYNDROME ... paraneoplastic syndrome
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