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differential ana antinuclear table vasculitis classification management patterns arthritis associations comparison cryoglobulinemia cryoglobulins pathophysiology primary signs sjogrens tafro testing thrombocytopenia
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Syndrome (SS), ... • Rheumatic Diseases ... : Lupus (SLE), Systemic ... Arthritis, Sjögren Syndrome ... #rheumatology #diagnosis
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Associated Rheumatic ... Diseases: • Homogeneous ... tissue disease ... Syndrome (SS), ... #rheumatology #diagnosis
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
their Disease Associations ... Anti-CCP, Rheumatoid ... Anticentromere - CREST syndrome ... La) - Sjogren's syndrome ... Goodpasture's syndrome
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... vasculitis, rheumatoid ... rheumatologic diseases ... Shrinking lung syndrome ... #Diagnosis #Rheumatology
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
Primary Sjogren’s Syndrome ... diseases • In ... Sjögren's, the syndrome ... diseases like rheumatoid ... lupus erythematosus
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Lupus Erythematosus ... Evolution: Chronic disease ... #lupus #sle #comparison ... #table #rheumatology ... #diagnosis #management
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
and Systemic lupus ... Association with disease ... overlap syndromes ... with auto-immune diseases ... #diagnosis #rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... Diseases • Septic ... lupus erythematosus ... #Disease #Rheumatoid ... #workup #diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Mucocutaneous lymph node syndrome ... VASCULITIS: • Behçet Syndrome ... • Cogan Syndrome ... : Systemic rheumatic ... as systemic lupus
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
diseases: - 10% ... respectively, having rheumatoid ... Elevated serum rheumatoid ... lupus erythematosus ... (SLE), rheumatoid
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