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diagnosis antibodies lupus disease erythematosus management patterns sle table antibody antineutrophil aortitis arthritis autoimmune comparison druginduced hematology laboratory monoclonal myopathy
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... antibodies) • Systemic ... scleroderma) - Anti-Scl ... cases • Sjögren syndrome ... antibodies #diagnosis #rheumatology
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... SLE), Sjogren's Syndrome ... @AnnKumfer #Antinuclear ... #Antibodies #ANA ... #patterns #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... (ANA) ANA or Anti-NucIear ... SLE), Sjogren's Syndrome ... #patterns #rheumatology ... #diagnosis #differential
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
arteritis, Cogan's Syndrome ... Nodosa (PAN), ANCA ... : IgG4-Related Disease ... Arthritis (RA), Systemic ... #Diagnosis #rheumatology
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
IgG4-Related Disease ... female, asian • Systemic ... serum lgE, no autoantibodies ... (antinuclear antibodies ... #treatment #rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
and Systemic lupus ... searched for when ANA ... SLE-SSc-AlM overlap syndromes ... #autoantibodies ... #table #ANA
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... macular Vasculitis) Autoantibodies ... anemia due to cold IgG ... #Monoclonal #Differential ... #Diagnosis #Oncology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
: - ANA > ... 95% (IgG anti-chromatin ... of autoantibodies ... months to years) Systemic ... : - ANA >
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
findings (ANA, ... • Anti-Ro/SSA autoantibodies ... permanent alopecia Differential ... Diagnosis: • ANCA-associated ... antibodies • (-) ANA
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... affected joint • Systemic ... antibody (ANA) ... thus, a negative ANA ... multiple myeloma) • ANA
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