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diagnosis differential ana antibodies lupus vasculitis classification management patterns sle table antibody antineutrophil aortitis cryoglobulinemia cryoglobulins druginduced laboratory monoclonal paraproteinemias
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Associated Rheumatic ... Diseases: • Homogeneous ... connective tissue disease ... SLE), Sjogren's Syndrome ... #patterns #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Disease! ... diseases, but often ... • Rheumatic Diseases ... #patterns #rheumatology
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
polychondritis, Behcet's Disease ... Diseases: IgG4- ... Related Disease ... (IgG4-RD), Rheumatoid ... Differential #Diagnosis #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... connective tissue disease ... 90% • Anti-GBM disease ... antibodies #diagnosis #rheumatology ... #diseases
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Decade Skin Disease ... Still disease, ... diseases (i.e. ... ) • Kikuchi disease ... #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
(Granulomatous disease ... rheumatic diseases ... atherosclerotic disease ... most important diseases ... differential #diagnosis #rheumatology
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
IgG4-Related Disease ... female, asian • Systemic ... , rheumatoid factor ... #Related #Disease ... #treatment #rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... Diseases • Septic ... connective-tissue disease ... #Disease #Rheumatoid ... #testing #Rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Association with disease ... with auto-immune diseases ... #autoantibodies ... #erythematosus ... #diagnosis #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Constitutional symptoms, Arthritis ... 95% (IgG anti-chromatin ... Lupus Erythematosus ... Evolution: Chronic disease ... #table #rheumatology
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