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diagnosis antinuclear associations vasculitis antineutrophil arthritis autoimmune classification disease laboratory lupus myopathy patterns rheumatic rheumatoid sle testing
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
others (RNP, aPL antibodies ... • Scleroderma (Systemic ... Ill • ANCA Vasculitis ... : P-ANCA (perinuclear ... #associations #table
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and ... ANA - Non-specific ... c-ANCA - Vasculitis ... granulomatosis p-ANCA ... antibodies
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antibody) and ANCA ... ) • Systemic lupus ... erythematosus ... cases • Sjögren syndrome ... #rheumatology #
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
(ANA) ANA or Anti-NucIear ... Antibody refers ... , Myositis, Mixed ... #rheumatology #diagnosis ... #differential
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Eosinophilia, asthma, chronic ... Vasculitis: + MPO-ANCA ... LFT • ESR • ANA ... ) pattern: antibodies ... #rheumatology #
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
findings (ANA, ... • Anti-Ro/SSA autoantibodies ... permanent alopecia Differential ... Diagnosis: • ANCA-associated ... with Lupus: • Chronic
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... ischemia • Skin: Erythematous ... Conjunctivitis, mucositis ... Eosinophilia, asthma, chronic ... #Rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... lupus erythematosus ... (ANA) test; if ... antibodies, which ... thus, a negative ANA
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
• Anti-NXP2 (ANA ... (ANA present 80% ... or head drop • ANA ... Mechanic's hands Autoantibodies ... • Conduction system
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