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RHABDOMYOLYSIS
•	Characterized by skeletal muscle breakdown & necrosis. 
•	Elevated Creatine kinase (CK) hallmark of rhabdomyolysis. 
•	Defined based
Creatine kinase (CK ... ) hallmark of rhabdomyolysis ... Defined based on CK ... • Half-life of CK ... and cefdinir #CK
Creatine kinase (CK) is an intracellular enzyme present in skeletal muscle, myocardium & brain; smaller amounts
Creatine kinase (CK ... CK may increase ... creatine kinase (CK ... are the hallmark ... CK functions as
Here are the morphological hallmarks of Rhabdomyosarcoma.

 - Broken arrow sign 

 - tad-pole rhabdomyoblasts
morphological hallmarks ... Rhabdomyosarcoma #Hallmarks
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Kidney Injury - AKI Workup ... Rhabdo-myolysis: CK ... syndrome: troponin, CK-MB ... #Injury #AKI #Workup
Myositis and Myopathies
Polymyositis 
 • Progressive, symmetric muscle weakness 
 • Elevated CK, +Anti-Jo, +Anti-Mi2
Dermatomyositis
weakness • Elevated CK ... rash • Elevated CK ... Elevated ESR, Normal CK ... mildly elevated CK ... Myositis: elevated CK
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Weakness, Normal CK ... Weakness, Incr CK ... therapy), Normal CK
Creatine Kinase - Causes of Elevated CK Levels
Acute CK Elevation (Pain > Weakness):
 • RHABDOMYOLYSIS
Causes of Elevated CK ... Levels Acute CK ... ASYMPTOMATIC: Macro CK ... Kinase #Elevated #CK
Usmle step 2 ck
Pulmonary diseases (High yield points)
#usmle #algorithm
Usmle step 2 ck
Inflammatory Myopathies
Dermatomyositis
 • Onset: Subacute
 • Pattern: Proximal
 • CK: Up to 50X ULN
 • Autoantibodies:
: Proximal • CK ... : Proximal • CK ... : Proximal • CK ... and distal • CK
Causes of Approach to Altered Level of Consciousness - Workup
Clinical Exam - Focal
 • Trauma
 •
Consciousness - Workup ... Refer to Blood Work ... Altered #ALOC #Workup ... #diagnosis #workup