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diagnosis differential hematology anemia causes management common cvid evaluation extravascular hemolysis hepatitis hepatology hypogammaglobulinemia immunodeficiency immunology injury intravascular liver myositis
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. TTP/HUS indicates thrombotic
Algorithm for workup ... purpura/hemolytic ... uremic syndrome ... , Hematology 2012 ... #Differential #Algorithm
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
) - HELLP syndrome ... microangiopathy: Thrombotic thrombocytopenic ... uremic syndrome ... Immune-mediated: - Autoimmune ... idiopathic) - Autoimmune
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Differential Diagnosis Algorithm ... methotrexate) • Drugs Autoimmune ... Non-lmmune: • HELLP Syndrome ... #Causes #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... Schistocytes, thrombocytopenia ... elliptocytosis, autoimmune ... Differential #Diagnosis #Algorithm ... #workup #hematology
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... anti-synthetase syndrome ... Around half of anti-SRP ... after 2 years of treatment ... Myositis #diagnosis #rheumatology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Differential Diagnosis Algorithm ... blood loss, Acute hemolysis ... Rebound effect from treatment ... Kawasaki, Nephrotic syndrome ... Differential #Diagnosis #Algorithm
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... vein: Budd-chiari syndrome ... Celiac disease • Autoimmune ... : Autoimmune hepatitis ... rises later - Half-life
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
specifically immune thrombocytopenia ... and autoimmune ... hemolytic anemia ... : • Nephrotic syndrome ... (Epstein-Barr syndrome
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
standing for: - Thrombocytopenia ... mesothelioma, etc - Autoimmune ... Hypoalbuminemia Treatment ... diagnosis #management #rheumatology ... #Thrombocytopenia
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