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diagnosis differential algorithm management analysis aplastic blood causes clinical common corticosteroids cvid ferritin folate folicacid hemolysis hypogammaglobulinemia immunodeficiency immunology interpretation
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
formerly known as atypical ... • Severe B12 deficiency ... anemia" • HELLP ... differential #diagnosis #hematology ... #hemolysis
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
Microangiopathic hemolytic ... Microspherocytes: Autoimmune hemolytic ... Bite cells: G6PD deficiency ... Alcohol abuse, Heavy ... Smear #Analysis #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
80 fL) • Iron Deficiency ... • Bleeding • Hemolysis ... • Folate Deficiency ... #MCV #Classification ... Algorithm #Causes #Hematology
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Anemia - Differential ... extravascular) hemolysis ... Celiac disease, Tropical ... #Anemia #Differential ... Algorithm #ferritin #hematology
Etiologies of Folate Deficiency • Decreased dietary intake - uncommon in this era • Increased requirements
Etiologies of Folate Deficiency ... hemolytic anemia ... develop folate deficiency ... functional folate deficiency ... differential #diagnosis #hematology
Potency Ratings of Topical Corticosteroids • Ultra high (I): Augmented betamethasone dipropionate 0.05%, Clobetasol propionate 0.05%,
Potency Ratings of Topical ... Hydrocortisone 1%, 2.5% #Topical ... Corticosteroids #Potency #classification ... #steroids #dermatology ... #table #pharmacology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
, GATA2 deficiency ... , CTLA4 deficiency ... abnormalities typical ... than 50 years who have ... #oncology #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
infections • 68% have ... • Atypical microorganisms ... and autoimmune hemolytic ... anemia) • Systemic ... hypogammaglobulinemia #immunology #hematology
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