23 results
Inherited Qualitative Platelet Defects
Bernard-Soulier Syndrome
 • Defect of adhesion due to a lack of GP Ib/IX/V
, Large platelets ... myelofibrosis and splenomegaly ... Defects #comparison #table ... #differential # ... diagnosis #hematology
Causes of Thrombocytopenia.
Platelet counts may be depressed because of decreased production or due to increased platelet
Causes of Thrombocytopenia ... Platelet counts ... due to increased platelet ... #Diagnosis #Hematology ... #Differential #
Pancytopenia - Differential Diagnosis Algorithm
 • 12-13 g/dL,
 • ANC < 1800/uL,
 • platelet < 150,000/uL

Initial
Pancytopenia - Differential ... < 1800/uL, • platelet ... sequestration (splenomegaly ... MatthewHoMD #Pancytopenia ... #hematology #workup
Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
 • Defective aggregation to all agonists except ristocetin
 • Normal platelet,
Gplb receptor • Thrombcytopenia ... Von Willebrand Disease ... #disorders #hematology ... #hemepath #differential ... #diagnosis #Aggregometry
Thrombocytopenia - Differential Diagnosis and Management Framework for Low Platelets

#Thrombocytopenia #Differential #Diagnosis #Management #hematology #platelets
Thrombocytopenia ... - Differential ... Framework for Low Platelets ... #Differential # ... #hematology #platelets
Thrombocytopenia - Differential Diagnosis Algorithm

Decreased production:
 • Bone marrow suppression
 • Bone marrow failure
 • Bone
Thrombocytopenia ... - Differential ... Diagnosis Algorithm ... #Differential # ... #hematology #platelets
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Thrombocytosis - Elevated Platelet ... → Refer to hematology ... Vasculitides, IBD, Celiac disease ... Thrombocytosis #Platelets ... #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
RBC's secondary to platelet ... • Platelet defects ... NON-PALPABLE PURPURA: Platelet ... #Diagnosis #hematology ... #rheumatology #
Approach to Leukocytosis - Differential Diagnosis Algorithm

Features of hematologic malignancy:
 • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Leukocytosis - Differential ... Diagnosis Algorithm ... lymphadenopathy, petechiae, splenomegaly ... anemia, ↑ MCV, ↑/↓ platelets ... #hematology #WBC
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
and Platelet Disorders ... History: - Prior platelet ... ITP, unexplained pancytopenia ... #Platelet #Disorders ... #Workup #hematology