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diagnosis algorithm injury transaminitis causes acute biliary chemistry cholangitis cirrhosis dermatology dili disease function gastroenterology hepatobiliary hepatocellular idiosyncratic induced interpretation
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... Differential Diagnosis ... 1000): • DILI (Drug-induced ... ) • Non-hepatic ... Diagnosis #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Injury - Differential ... , Recreational Drugs ... Vasculature • Hepatic ... #Injury #Differential ... Acute #algorithm #hepatology
Hepatobiliary Manifestations of Sickle Cell Disease Acute sickle cell hepatic crisis: • Fever, acute onset RUQ pain,
Acute sickle cell hepatic ... hepatomegaly and anemia ... Liver transplant ... Hepatobiliary #hepatology ... #hepatitis #differential
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... • Alcoholic hepatitis ... • Others #LFTs ... #Hepatology #LiverEnzymes
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
• Infections: Hepatitis ... valproate, azoles), Drugs ... #Diagnosis #hepatology ... Transaminitis #LFTs ... #hepatitis
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Idiosyncratic Drug-induced ... Chronic - ongoing ↑ LFTs ... Idiosyncratic #differential ... gastroenterology #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... replaced by non-hepatic ... chemistry #diagnosis #differential ... #Hepatology #transaminitis ... #LFTs #RValue #
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Secondary Causes: - Drug ... - Hemolytic anemia ... deficiency • Liver ... #Diagnosis #hematology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
bile ducts Differential ... Diagnosis: • Viral hepatitis ... malignancies, Hepatic ... , Sarcoidosis, Drug-induced ... diagnosis #workup #hepatology
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