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Treatment of Bleeding in Selected Inherited Disorders of Hemostasis

#Bleeding #Disorders #HemophiliaA #HemophiliaB #Management #Table #Treatment
Treatment of Bleeding ... Hemostasis #Bleeding ... #Disorders #HemophiliaA ... #HemophiliaB #Management
Hemophilia A Prophylaxis (Factor Eight Deficiency)

Who Needs Prophylaxis?

Primary Prophylaxis:
 • Severe deficiency (activity level <1%) even
Hemophilia A Prophylaxis ... without hx of bleeding ... Prophylaxis: • 2 bleeding ... @jlberrymd #Hemophilia ... #HemophiliaA #Prophylaxis
Hemophilia - Diagnosis and Management
Diagnosis:
 • Consistent bleeding history (unless screening for disease in family members
Hemophilia - Diagnosis ... • Consistent bleeding ... • Establish hemophilia ... Treatment - Acute Bleeding ... serious or moderate bleeding
Von Willebrand Disease Classification
Type 1 (Accounts for ~3/4 of cases):
 • Defect: Quantitative defect (i.e. not
Autosomal dominant • Bleeding ... (uncommon) • Bleeding ... recessive • Bleeding ... Clinically similar to hemophilia
Hemophilia
#Management #Peds #HemophiliaA #HemophiliaB #PEMSource
Hemophilia #Management ... #Peds #HemophiliaA ... #HemophiliaB #PEMSource
Forrest Classification for Peptic Ulcer Bleeding
Rebleeding risks are without endoscopic intervention
1a - Spurting Bleed - 60-100%
Bleed - 60-100% Re-bleeding ... Bleed - 50% Re-bleeding ... IIa - Non-Bleeding ... Clot - 20-30% Re-bleeding ... Peptic #Ulcer #Bleeding
An AAV5 vector with a functional factor VIII gene tested in men with hemophilia A #EBM
tested in men with hemophilia ... A #EBM #Honc #hemophilia
Helpful Clinical Features in Evaluating Bleeding Disorders
Age of onset
 • Neonate - in 20% of haemophilias,
Neonate - in 20% of haemophilias ... , bleeding occurs ... • Toddler — haemophilias ... boys, suggests haemophilia ... characteristic of haemophilia
REBEL Review 79: Treatment of Hemophilia 

Walkina Out of Pt Room, You Should Know... 
1. Type
: Treatment of Hemophilia ... Type of Hemophilia ... Activity*) #hemophilia
Forrest Classification for Describing Endoscopic Findings in Patients With Bleeding Ulcers and Predicting Risk of Rebleeding

Classification
Patients With Bleeding ... Predicting Risk of Rebleeding ... Diet I Active bleeding ... II Stigmata of bleeding ... Endoscopy #EGD #Risk #Rebleeding