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differential rheumatology cardiology symptoms algorithm causes management workup infectiousdiseases arthritis classification endocarditis erythematosus hemolytic hypertension infections lung lupus rheumatoid sle
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
autoimmune disease ... skin thickening Signs ... ), PAH (pulmonary ... #diagnosis #signs ... #symptoms #testing
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
- Differential Diagnosis ... deficiency • Fanconi’s anemia ... : • Systemic lupus ... Antibody-mediated hemolysis ... #Hematology
Systolic Murmurs - Differential Diagnosis Algorithm Benign / Flow / Hyperdynamic: • Pregnancy • Fever • Anemia Supravalvular
Systolic Murmurs ... - Differential Diagnosis ... • Fever • Anemia ... Rheumatic Heart Disease ... Pulmonary Stenosis
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Endocarditis, Aortic ... pain (20%) Renal disease ... ) Blood (75%): Anemia ... erythematosus #signs ... #symptoms #diagnosis
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Fever, Hematuria, Hemoptysis ... Differential Diagnosis ... Immune Complex: Systemic ... testing: anti-ANCA ... #differential #diagnosis
Clinical Classification of Pulmonary Hypertension 1. Pulmonary arterial hypertension from pulmonary vasculopathy Idiopathic pulmonary arterial hypertension Heritable gene mutations
Chronic hemolytic anemia ... Systolic dysfunction ... multifactorial mechanisms Hematologic ... disorders, lenectomy Systemic ... Classification #Diagnosis
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential Diagnosis ... elliptocytosis, autoimmune hemolysis ... Algorithm #workup #hematology ... #testing
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Iron Deficiency Anemia ... extravascular) hemolysis ... athletic training, Pulmonary ... Structural: Celiac disease ... Algorithm #ferritin #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
anemia • Cold ... Positive Coombs testing ... • Compensated hemolysis ... intravascular hemolysis ... #hematology #diagnosis
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... - Hemolytic anemia ... sclerosis, Still's disease ... autoantibodies #signs ... #differential #rheumatology
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