17 results
Key Characteristics of Old and New Potassium-Binding Agents

- Dr. Edgar V. Lerma https://twitter.com/edgarvlermamd

#Potassium #Binding #KBinders #Kayexelate
edgarvlermamd #Potassium ... #Binding #KBinders ... Kayexelate #Comparison #Table ... Pharmacology #Patiromer #HyperKalemia ... #Nephrology #Agents
Hyperkalemia - Differential Diagnosis - Impaired Excretion vs Redistribution

Impaired Urinary Excretion 
 - Renal failure
 -
Hyperkalemia - Differential ... lysissyndrome - Massive Hemolysis ... - Rhabdomyolysis ... - Exercise - Hyperkalemic ... Differential #Diagnosis #Table
Potassium Binders for Management of Hyperkalemia
 • SPS - Sodium polystyrene sulfonate
 • Patiromer (veltassa)
 •
Potassium Binders ... Management of Hyperkalemia ... #Hyperkalemia # ... #pharmacology #table ... #comparison #nephrology
Hyperkalemia: Diagnostic algorithm
Decreased renal potassium excretion
 • Acute renal failure
 • Chronic renal failure
 • Drugs
Increased
Hyperkalemia: Diagnostic ... Decreased renal potassium ... • Tumor lysis/hemolysis ... • Type 1 #Hyperkalemia ... Diagnosis #algorithm #nephrology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
venipuncture • Hemolysis ... • Recent IV potassium ... cell lysis: - Hemolysis ... lysis syndrome - Rhabdomyolysis ... #high #nephrology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
venipuncture • Hemolysis ... • Recent IV potassium ... cell lysis: - Hemolysis ... lysis syndrome - Rhabdomyolysis ... #high #nephrology
Potassium-Binding Agents to Treat Hyperkalemia
Sodium zirconium cyclosilicate (Lokelma):
 • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... Agents to Treat Hyperkalemia ... of aspiration #Potassium ... #pharmacology #table ... #comparison #binders
Causes of HyperKalemia - Differential Diagnosis
Increased extracellular K+:
 • Tissue injury
 • Hemolysis
 • Rhabdomyolysis
 •
Causes of HyperKalemia ... Tissue injury • Hemolysis ... • Rhabdomyolysis ... blockers - MCW Nephrology ... MCW_Nephrology #HyperKalemia
Phosphate binders - quick reference chart of maximum daily dose. Most patients with CKD will require
Phosphate binders ... since they are not able ... aluminum-based phosphate binder ... restricted due to hypercalcemia ... Only* #CKD #Nephrology
Causes of Hyperkalemia
Pseudohyperkalemia
 - Tourniquet use
 - Hemolysis (in vitro)
 - Leukocytosis
 - Thrombocytosis
Intra- to extracellular
Causes of Hyperkalemia ... Tourniquet use - Hemolysis ... intoxication - Hyperkalemic ... aged blood - Hemolysis ... chemotherapy - Rhabdomyolysis