1390 results
Pharmacokinetic Characteristics and Primary Routes of Clearance of Oral Anticoagulant Agents

Warfarin - 100% Hepatic, 0% Renal
Apixaban
Warfarin - 100% Hepatic ... Apixaban - 75% Hepatic ... Dabigatran - 20% Hepatic ... Edoxaban - 50% Hepatic ... NOAC #Metabolism #Pharmacology
Pharmacologic prophylaxis of VTE in selected clinical scenarios.

Enoxaparin 
Dalteparin 
Fondaparinux 
Dabigatran 
Unfractionated Heparin
Warfarin 
Aspirin 

#prophylaxis #VTE
Pharmacologic prophylaxis ... Unfractionated Heparin ... #indications #pharmacology
Mechanism of Action of Bile Acid Sequestrants
Bile Acid Sequestrants → ↓ Hepatic Bile Acid Pool →
Sequestrants → ↓ Hepatic ... Acid Pool → ↑ Hepatic ... pathophysiology #pharmacology
Heparin and Low Molecular Weight Heparin (LMWH)–Mediated Inactivation of Thrombin or Factor Xa 
 - Interaction
Heparin and Low ... Molecular Weight Heparin ... antithrombin with heparin ... Unfractionated heparin ... #LMWH #Pharmacology
Lactulose: Mechanism of Action in Hepatic Encephalopathy
Lactulose → ↑ Lactic Acid, Acetic Acid → ↓ pH
Mechanism of Action in Hepatic ... #Lactulose #pharmacology
Anticoagulant specific factor inhibition. 

#anticoagulation #clotting #INR #heparin #LMWH #NOAC #warfarin #coumadin #rivaroxaban  #Xarelto #apixaban
clotting #INR #heparin ... Pradaxa #management #pharmacology
Coagulation Cascade - Actions of Anticoagulants
 • Heparin: Unfractionated heparin, Enoxaparin, Daltaparin
 • Fondaparinux
 • Direct
Anticoagulants • Heparin ... Unfractionated heparin ... anticoagulation #pharmacology
LOW MOLECULAR WEIGHT HEPARIN (LMWH) DOSING RECOMMENDATIONS (Enoxaparin and Dalteparin):
 - VTE PROPHYLAXIS
 - VTE TREATMENT
MOLECULAR WEIGHT HEPARIN ... #Prophylaxis #Pharmacology
Heparin - Unfractionated Heparin (UFH) vs Low-Molecular-Weight Heparin (LMWH)
UFH:
 • Advantages: 
    -
Heparin - Unfractionated ... Heparin (UFH) vs ... Low-Molecular-Weight Heparin ... as compared to heparin ... Unfractionated #pharmacology
Choice of anticoagulant for treatment of pulmonary embolism
 • Malignancy - LMWH
 • To avoid parenteral
edoxaban; VKA • Hepatic ... anticoagulation #pharmacology