531 results
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Liver Chemistry ... ALT: • AST: liver ... In liver, 80% of ... primarily within liver ... Synthesis: in hepatocyte
Histologic Features and Prevalence of Nonalcoholic Steatohepatitis (NASH). NASH is a potentially progressive type of nonalcoholic
nonalcoholic fatty liver ... features of NASH in liver-biopsy ... specimens: ballooned hepatocytes ... cirrhosis, and primary liver
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... infiltrates maternal hepatocytes ... → Liver dysfunction ... malaise) → Acute liver ... Transfer to a liver
Commonly Observed Laboratory Findings in Hepatic / Liver Failure
 - Elevated conjugated and unconjugated bilirubin -
Findings in Hepatic / Liver ... fold with acute liver ... permanent loss of hepatocytes ... ; in chronic liver ... has exhausted liver
NAFLD Activity Score (NAS)
0–3 for steatosis
0–3 for inflammation
0–2 for ballooning hepatocytes
NAS ≥5 is classified as definitive
for ballooning hepatocytes ... a simple fatty liver
N-Acetyl Cysteine (NAC) Therapy Mechanism of Action: The non-toxic route of APAP metabolism gets saturated in
other routes of liver ... the extent of hepatocyte
Bile acids are the end products of cholesterol catabolism. Cholic acid and chenodeoxycholic acid are the
synthesized in human livers ... Human liver synthesizes ... circulation to liver ... taken up into hepatocytes ... synthesis in the liver
Causes of Hyperferritinemia - Differential Diagnosis
Ferritin > 1000
Ferritin is the storage form of iron. Increased hepcidin
leaving enterocytes, hepatocytes ... is made in the liver
ANTI-MDA5 DERMATOMYOSITIS

Cutaneous manifestations:
• Periorbital heliotrope (blue-purple) rash with edema
• Erythematous rash on the face, or the
disease and ILD • Liver ... Liver biopsies show ... steatosis and hepatocyte
Pathology - Hepatocyte Pigments

Lipofuschin (H&E) 

Alpha-I-antitrypsin globules (PAS-D) 

Mallory's hyaline / Mallory Denk Bodies 

Giant Mitochondria
Pathology - Hepatocyte ... bilirubinostasis (H&E) #Hepatocyte