133 results
Histologic Features and Prevalence of Nonalcoholic Steatohepatitis (NASH). NASH is a potentially progressive type of nonalcoholic
nonalcoholic fatty liver ... disease (NAFLD) ... specimens: ballooned hepatocytes ... cirrhosis, and primary liver ... Epidemiology #NASH #NAFLD
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Elevated Liver Function ... 100-500): • NAFLD ... (Drug-induced liver ... ) • Non-hepatic ... LouLectures #Liver
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Liver Chemistry ... ALT: • AST: liver ... In liver, 80% of ... primarily within liver ... Synthesis: in hepatocyte
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Causes of Acute Liver ... Hepatocellular - Liver ... Antitrypsin • Other: NAFLD ... Vasculature • Hepatic ... Congestion/CHF • Hepatic
NAFLD / NASH Progression Timeline
Healthy Liver → NAFLD/NASH → 0.25-3.2%/year → Cirrhotic NASH → 0.3-2.6%/year →
NAFLD / NASH Progression ... Timeline Healthy Liver ... → NAFLD/NASH → ... /year → HCC • NAFLD ... Polymorphisms, Age #NAFLD
Hepatic Portal Venous System Drainage Anatomy
1) Most of the blood from abdominal organs goes into the
Hepatic Portal Venous ... goes into the hepatic ... is delivered to hepatocytes ... capillaries of hepatic ... IVC using the hepatic
Non-alcoholic fatty liver disease algorithm.
 
For those patients with NAFLD or liver disease of unknown aetiology,
Non-alcoholic fatty liver ... patients with NAFLD ... or liver disease ... likelihood of liver ... ELF, enhanced liver
Pathogenesis of Nonalcoholic Steatohepatitis. Various factors, including inflammation, hyperinsulinemia or insulin resistance, and altered lipid homeostasis,
develop in fatty hepatocytes ... #GI #IM #NASH #NAFLD
NAFLD Activity Score (NAS)
0–3 for steatosis
0–3 for inflammation
0–2 for ballooning hepatocytes
NAS ≥5 is classified as definitive
NAFLD Activity Score ... for ballooning hepatocytes ... a simple fatty liver ... .2020.603926 #NAFLD
Commonly Observed Laboratory Findings in Hepatic / Liver Failure
 - Elevated conjugated and unconjugated bilirubin -
Laboratory Findings in Hepatic ... / Liver Failure ... permanent loss of hepatocytes ... ; in chronic liver ... #LiverFailure #Hepatic