44 results
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Elevated Liver Function ... Tests (LFTs) - ... 100-500): • NAFLD ... (Drug-induced liver ... Function #Tests #LFTs
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Liver Chemistry ... ALT: • AST: liver ... In liver, 80% of ... primarily within liver ... Pathophysiology #Diagnosis #LFTs
Histologic Features and Prevalence of Nonalcoholic Steatohepatitis (NASH). NASH is a potentially progressive type of nonalcoholic
nonalcoholic fatty liver ... disease (NAFLD) ... specimens: ballooned hepatocytes ... cirrhosis, and primary liver ... Epidemiology #NASH #NAFLD
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... Hemochromatosis • NAFLD ... ALT < 5x ULN • NAFLD ... • Others #LFTs
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Wilson's, HH, NAFLD ... 5x ULN - NAFLD ... Burak @kwburak #LFTs
NAFLD / NASH Progression Timeline
Healthy Liver → NAFLD/NASH → 0.25-3.2%/year → Cirrhotic NASH → 0.3-2.6%/year →
NAFLD / NASH Progression ... Timeline Healthy Liver ... → NAFLD/NASH → ... /year → HCC • NAFLD ... Polymorphisms, Age #NAFLD
Liver Function Tests (LFTs)
 - Aspartate aminotransferase (AST) 
 - Alanine aminotransferase (ALT) 
 - Alkaline
Liver Function Tests ... (LFTs) - Aspartate ... Prothrombin #Liver ... Function #Tests #LFTs
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver ... Diagnosis Framework: Liver ... Injury → liver ... antitrypsin • Other: NAFLD ... Transaminitis #LFTs
Non-alcoholic fatty liver disease algorithm.
 
For those patients with NAFLD or liver disease of unknown aetiology,
Non-alcoholic fatty liver ... patients with NAFLD ... or liver disease ... likelihood of liver ... ELF, enhanced liver
Pathogenesis of Nonalcoholic Steatohepatitis. Various factors, including inflammation, hyperinsulinemia or insulin resistance, and altered lipid homeostasis,
develop in fatty hepatocytes ... #GI #IM #NASH #NAFLD